Maximum Transmission Unit. This specifies the maximum size for the data portion of an IP packet transmitted on the interface.
Datagrams are sized or fragmented according to the MTU of the interface on which they are transmitted.
XRPi allows MTU's up to 1500 bytes, but setting MTU over 256 is not recommended on AX25 ports, because the buffer size on TNC-based nodes is usually only big enough for a 256-byte data field.
This is a mandatory keyword, although for some interface types the value has no meaning and is ignored. If in doubt, use 256.